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    Molecular Mechanisms of Ischemic Tolerance in the Brain

    Submission Deadline: October 30, 2022

    Guest Editor

    Dr. Agnese Secondo E-Mail

    Associate Professor, Department of Neuroscience, School of Medicine, Federico II University of Naples, Italy.

    Research Keywords: calcium homeostasis; calcium storing organelles; ER stress; stroke; ischemic tolerance; autophagy; ALS


    About the Special Issue

    Sublethal hypoxic or ischemic events can improve the tolerance of not only cells or tissues, but also of entire organs, to subsequent hypoxic or ischemic harmful episode. This phenomenon is called ischemic preconditioning. The terms preconditioning and tolerance were first used in this context in the 1960s. In addition, a variety of physical and pharmacological stimuli can also induce ischemic tolerance. While its clinical use is still lacking, tolerance has been speculated to play a protective role in cerebral ischemia. From this date, a plethora of studies contributed to the identification of the molecular mechanisms underlying ischemic tolerance.

    In this respect, various forms of pretreatment stimulation can trigger endogenous protection or regeneration mechanisms through various signaling molecules and pathways, thus triggering an early or delayed adaptive response.

    The early adaptation is thought to be a consequence of alterations in ionic homeostasis, ion channel permeability, protein phosphorylation, and other post-translational modifications. In contrast, delayed ischemic preconditioning, known as ‘classical preconditioning’, requires gene activation and de novo protein synthesis. This manifests itself only hours to days following preconditioning and involves both the inhibition of detrimental mechanisms or increase in survival and repair mechanisms.

    With this special issue, we would like to participate to the general investigation on the molecular pathways determining tolerance with particular emphasis to the ionic mechanisms.

    Keywords: ischemic tolerance; calcium homeostasis; calcium storing organelles; ER stress; autophagy; neurodegeneration

    Call for Papers

    Published Articles

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    • Aims and Scope
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    • Ongoing Special Issues
      Neuroprotective Nitric Oxide and Its Metabolites (Nitrite and Nitrate)
      Cognitive Alterations in Psychiatry
      Glia and Neuroprotection
      The Future of Biomarkers in CNS Diseases
      Biomarkers in Amyotrophic Lateral Sclerosis
      Molecular Mechanisms of Ischemic Tolerance in the Brain
      Recent Advances in Neurochemistry and Genetics of Late-onset Alzheimer's Disease
      The Search for Biomarkers: from Diagnosis to Progression Assessment
      Parkinson's Disease: Principal Targets and Interventional Mechanisms
      Intervention of Neuroimmune Responses
      Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
      The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
      New Advances in Imaging Techniques for the Evaluation of Neurological Disorders
      Natural Products in Neurotherapeutic Applications
      Penetrance and Metabolism of Brain Drugs
      Therapeutic Targets for Neuroprotection in Ischemic Stroke
      Neuroinvasion, Neuropathogenesis and Neuroprotective Agents in the Pathophysiology of SARS-CoV-2
      Empower Yourself - Physical Activity as Prevention and Rehabilitation of Neurological and Psychiatric Diseases
      Neuro-Inflammation as a Target in the Design of Multifunctional Drug Candidates for Neurodegenerative Diseases
      Dry Needling for Neurological Disorders
      Peripheral Nerve Regeneration
      Defending the Brain and the Mind: Exploring Neuroprotective Therapies for Mental Health Disorders
      Synaptic Pruning and Autophagy: from Physiology to Pathology
    • Completed Special Issues
      Cholesterol Dyshomeostasis in Neurological Diseases
      Emerging Concepts in Subarachnoid Hemorrhage
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