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  • Special Issue Topic

    Neuroprotective Nitric Oxide and Its Metabolites (Nitrite and Nitrate)

    Submission Deadline: April 30, 2022

    Guest Editor

    Prof. Hyun-Ock Pae E-Mail

    Department of Microbiology & Immunology, School of Medicine, Wonkwang University, Iksan, Republic of Korea

    Research Keywords: nitric oxide; nitric oxide metabolites; NOS; carbon monoxide; heme oxygenase-1; hydrogen sulfide


    About the Special Issue

    Nitric oxide (NO), which is known as a bioactive substance, is produced in humans by the following two pathways and exhibits various pharmacological effects. (1) First, NO is produced by NO synthase (NOS) existing in cells using the amino acid arginine (Arg) as a substrate, and this pathway is called as the Arg-NOS-NO pathway. (2) Secondly, NO is produced by NO reductase (NOR) using NO metabolites (nitrite and nitrate) as sources, and this pathway is called as the nitrate-nitrite-NO pathway. These two paths have the following advantages and disadvantages. (1) The positive advantage of the Arg-NOS-NO pathway is that it acts directly and selectively. The fatal disadvantage of this pathway is that if the NOS is damaged, no more NO will be produced and the disease will result from a lack of NO. (2) The positive advantage of the nitrate-nitrite-NO pathway is that NO metabolites can be supplied as foods and that NOR is abundantly present in our body and/or cells, therefore suggesting that NOR damage does not occur and that the nitrate-nitrite-NO pathway is compensating for the disadvantages of the Arg-NOS-NO pathway. The negative disadvantage of this pathway is that NO metabolites must be continuously supplied. Thanks to two NO pathways, we now understand that NO is continuously produced everywhere and works on all tissues, including the brain. It is time to start to investigate and discuss the protective effects of NO and its metabolites (nitrite and nitrate) against neuronal damage.

    Keywords: nitric oxide; nitrite; nitrate; diabetes; nitric oxide synthase; nitrite reductase; cardiovascular diseases; atherosclerosis; neurodegenerative diseases

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    Published Articles

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    • Ongoing Special Issues
      Neuroprotective Nitric Oxide and Its Metabolites (Nitrite and Nitrate)
      Cognitive Alterations in Psychiatry
      Glia and Neuroprotection
      The Future of Biomarkers in CNS Diseases
      Biomarkers in Amyotrophic Lateral Sclerosis
      Molecular Mechanisms of Ischemic Tolerance in the Brain
      Recent Advances in Neurochemistry and Genetics of Late-onset Alzheimer's Disease
      The Search for Biomarkers: from Diagnosis to Progression Assessment
      Parkinson's Disease: Principal Targets and Interventional Mechanisms
      Intervention of Neuroimmune Responses
      Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
      The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
      New Advances in Imaging Techniques for the Evaluation of Neurological Disorders
      Natural Products in Neurotherapeutic Applications
      Penetrance and Metabolism of Brain Drugs
      Therapeutic Targets for Neuroprotection in Ischemic Stroke
      Neuroinvasion, Neuropathogenesis and Neuroprotective Agents in the Pathophysiology of SARS-CoV-2
      Empower Yourself - Physical Activity as Prevention and Rehabilitation of Neurological and Psychiatric Diseases
      Neuro-Inflammation as a Target in the Design of Multifunctional Drug Candidates for Neurodegenerative Diseases
      Dry Needling for Neurological Disorders
      Peripheral Nerve Regeneration
      Defending the Brain and the Mind: Exploring Neuroprotective Therapies for Mental Health Disorders
      Synaptic Pruning and Autophagy: from Physiology to Pathology
    • Completed Special Issues
      Cholesterol Dyshomeostasis in Neurological Diseases
      Emerging Concepts in Subarachnoid Hemorrhage
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