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    Neuroinvasion, Neuropathogenesis and Neuroprotective Agents in the Pathophysiology of SARS-CoV-2

    Submission Deadline: July 31, 2023

    Guest Editor

    Prof. Ebenezer Olatunde Farombi E-Mail

    Professor of Biochemistry and Molecular Toxicology, and Director, Molecular Drug Metabolism and Toxicology Laboratories, College of Medicine, University of Ibadan, Nigeria

    Research Keywords: molecular pharmacology and toxicology; cellular oxidative stress mechanisms; environmental toxicology; antioxidant redox biochemistry; nutrigenomics; natural product pharmacology


    About the Special Issue

    COVID-19 is known basically to be a respiratory disease with the main route of entry into the body via inhalation. However, it is known that SARS-CoV-2 affects extra pulmonary organ systems including the CNS as the virus has been detected in many brain tissues including the choroid plexus, meningeal vessels, neurons and CSF. Despite the detection of SARS-CoV-2 in the brain especially from infected patients, there is dearth of knowledge on how it gets there. However, based on the normal route of infection of the virus, it is believed that the olfactory mucosa is a possible route into the brain. Observations from rodents, COVID-19 patients and autopsies from patients who died of COVID-19 reveal that ACE2 is involved in the neuroinvasion of SARS-CoV-2. Neuropathogenesis studies of SARS-CoV-2 infection in non-human primates show neuroinflammation, microhemorrhages, brain hypoxia, neuron degeneration, autoimmune dysfunction, oxidative stress, mitochondrial dysfunction, and apoptosis. This information will prove invaluable in the selection of novel candidates and search for new therapeutic agents with adequate penetration into relevant regions of the CNS. Neuroprotection, an attractive strategy aims to protect the nervous system from injury and damage from infective agents including SARS-CoV-2. Neuroprotective agents include drugs and phytochemicals widely distributed in plants used traditionally in the management of several ailments including viral infections. The bioactive compounds in these plant substances are currently been identified using a battery of pharmacology and molecular docking methods. For instance, flavonoids and semi-synthetic flavonoid derivatives with potent antioxidant, anti-inflammatory, antiviral and neuroprotective properties have been developed that block multiple pathological neurodegenerative pathways.

    The goal of this special issue is to gather studies on neuroinvasion and neuropathogenesis of SARS-CoV-2 and therapeutic interventions against the infection. These contributions will include review and systematic review articles, original research, clinical, case studies, and drug trials.

    Keywords: neuroinvasion; neuropathogenesis; SARS-CoV-2; COVID-19; neuroinflammation; neuroprotection; phytochemicals

    Call for Papers

    Published Articles

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    • Aims and Scope
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    • Ongoing Special Issues
      Neuroprotective Nitric Oxide and Its Metabolites (Nitrite and Nitrate)
      Cognitive Alterations in Psychiatry
      Glia and Neuroprotection
      The Future of Biomarkers in CNS Diseases
      Biomarkers in Amyotrophic Lateral Sclerosis
      Molecular Mechanisms of Ischemic Tolerance in the Brain
      Recent Advances in Neurochemistry and Genetics of Late-onset Alzheimer's Disease
      The Search for Biomarkers: from Diagnosis to Progression Assessment
      Parkinson's Disease: Principal Targets and Interventional Mechanisms
      Intervention of Neuroimmune Responses
      Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
      The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
      New Advances in Imaging Techniques for the Evaluation of Neurological Disorders
      Natural Products in Neurotherapeutic Applications
      Penetrance and Metabolism of Brain Drugs
      Therapeutic Targets for Neuroprotection in Ischemic Stroke
      Neuroinvasion, Neuropathogenesis and Neuroprotective Agents in the Pathophysiology of SARS-CoV-2
      Empower Yourself - Physical Activity as Prevention and Rehabilitation of Neurological and Psychiatric Diseases
      Neuro-Inflammation as a Target in the Design of Multifunctional Drug Candidates for Neurodegenerative Diseases
      Dry Needling for Neurological Disorders
      Peripheral Nerve Regeneration
      Defending the Brain and the Mind: Exploring Neuroprotective Therapies for Mental Health Disorders
      Synaptic Pruning and Autophagy: from Physiology to Pathology
    • Completed Special Issues
      Cholesterol Dyshomeostasis in Neurological Diseases
      Emerging Concepts in Subarachnoid Hemorrhage
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    • Exploration of Neuroprotective Therapy
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