• Special Issue Topic

    Neuroinflammation in the Ageing and the Injured Brain

    Submission Deadline: March 15, 2023

    Guest Editors

    Prof. Ameneh Rezayof E-Mail

    Professor at the Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran

    Research Keywords: Neurobiology of memory formation, reward-related learning in drug addiction, and signaling pathways in emotional behaviours

    Dr. Maryam Sardari E-Mail

    Assistant Professor at the Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran

    Research Keywords: Stroke, neuroinflammation, glial activation, peripheral immune system, behavioral neuroscience

    About the Special Issue

    Immune system dysregulation is a significant consequence of aging. Pathological changes in central and peripheral immune responses trigger neuronal injury in humans and laboratory animals. Neuroinflammation can occur via activating microglial cells and other immune cells to increase the release of cytokines, reactive oxygen and nitrogen species, prostaglandins and growth factors in the aging brain. Age-related neuroinflammation is a central mechanism in Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative disorders commonly characterized by cognitive impairment, dementia, and disability. The sustained brain's immune activation may be correlated with the presence of amyloid β plaques and neurofibrillary tangles in AD pathogenesis. Microglia-derived oxidative stress plays a critical role in severe neuroinflammation and α-synuclein pathogenic alteration to induce progressive dopaminergic nigrostriatal degeneration associated with motor dysfunction in PD. Moreover, neuroinflammation and oxidative stress contribute to the dysregulation of cerebral blood flow and the breakdown of blood brain barrier implicated in the pathogenesis of age-associated neurodegenerative disorders.

    Neuroinflammation in the ageing and the injured brain is a special issue that focuses on the inflammatory mechanisms involved in age-related neurodegenerative diseases. This issue brings together work focusing on the critical role of central and peripheral neuro-immune interactions. Clinical and sub-clinical studies for integrative reviews and commentaries on brain neuroinflammation and neurodegeneration are encouraged and welcome.

    Keywords: Aging, neuroinflammation, neurodegenerative diseases

    Call for Papers

    Published Articles

    Open Access
    Mesenchymal stem cell stroke therapy: current limitations in its clinical translation
    For more than a decade now, research studies, proof of concept work, and clinical trials have endeavored to understand how mesenchymal stem cells might be used to help protect, repair, and/or regene [...] Read more.
    Ylenia Pastorello, Mark Slevin
    Published: June 28, 2023 Explor Neurosci. 2023;2:98–105
    DOI: https://doi.org/10.37349/en.2023.00015
    Times Cited: 0
    Open Access
    Cellular and molecular mechanisms of stress-induced memory impairment
    Exposure to stressful conditions plays a critical role in brain processes, including neural plasticity, synaptic transmission, and cognitive functions. Since memory-related brain regions, the hippocampus (Hip), the amygdala, and t [...] Read more.
    Ameneh Rezayof ... Shiva Hashemizadeh
    Published: December 30, 2022 Explor Neurosci. 2022;1:100–119
    DOI: https://doi.org/10.37349/en.2022.00008
    Times Cited: 0