• Special Issue Topic

    Extracellular Vesicles as Cell-based Therapeutics

    Submission Deadline: April 30, 2024

    Guest Editors

    Prof. Dirk M. Hermann E-Mail

    Professor of Vascular Neurology, Dementia and Ageing Research, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

    Research Keywords: Ischemic stroke, neuroprotection, neurorestoration, stem cells and extracellular vesicles

    Dr. Chen Wang E-Mail

    Department of Neurology, and Center for Translational and Behavioral Neurosciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

    Research Keywords: Ischemic stroke, neuroprotection, stem cells and extracellular vesicles, immunomodulation

    About the Special Issue

    Extracellular vesicles (EVs) are lipid bilayer-enclosed nanoparticles naturally released by virtually all cell types. Based on their biogenesis and size, EVs are typically classified as exosomes (60-150 nm), microvesicles (100-1,000 nm), and apoptotic bodies (50-2,000 nm). EVs carry various cargos such as proteins, lipids, nucleic acids, and organelles from their parental cells and have wide-ranging biological effects including mediation of intercellular communication, promotion of tissue regeneration, maintenance of tissue homeostasis, and immunomodulation. EVs’ diverse functions have attracted intense attention and EVs have emerged as a novel therapy option for neurological diseases, such as stroke, Alzheimer's disease, and multiple sclerosis. Despite extensive advancement in EV research, considerable challenges remain to be overcome before EVs can be applied in clinical practice.

    To prompt the development of EVs as novel neurotherapeutics, we welcome and appreciate studies evaluating therapeutic effects of EVs in neurological disease models, including but not limited to, investigating the efficacy of EVs, elucidating the mechanism of action and site of action of EVs, exploring EVs as disease biomarkers, engineering EVs as drug carriers, and identifying EV potency assays.

    Keywords: Extracellular vesicles, neurotherapeutics

    Call for Papers

    Published Articles

    Open Access
    Original Article
    Extracellular vesicles derived from mesenchymal stem cells ameliorate cognitive impairment caused by neuroinflammation in young but not aged mice
    Aim: The aim of this work was to study the effects of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) on inflammation-impaired cognitive functions and the brain of mice.  [...] Read more.
    Olena Lykhmus ... Vitalii Kordium
    Published: June 12, 2024 Explor Neurosci. 2024;3:207–218
    DOI: https://doi.org/10.37349/en.2024.00045
    Times Cited: 0
    Open Access
    Therapeutic potential of extracellular vesicles in Parkinson’s disease
    Globally, the incidence of Parkinson’s disease (PD) is increasing faster than other neurodegenerative disorders. Neuropathologically, PD is characterized by the loss of dopaminergic neurons in the [...] Read more.
    Michelli Ramires Teixeira ... Rodrigo Pinheiro Araldi
    Published: June 29, 2023 Explor Neurosci. 2023;2:106–122
    DOI: https://doi.org/10.37349/en.2023.00016
    Open Access
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    Times Cited: 0