• Special Issue Topic

    Hyperuricemia: current state and prospects

    Submission Deadline: August 31, 2024

    Guest Editor

    Dr. Blanka Stiburkova E-Mail

    Institute of Rheumatology, Prague, Czech republic & Department of Pediatrics and Inherited metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

    Research Keywords: Hyperuricemia, hypouricemia, gout, inherited metabolic disorder, purine metabolism

    About the Special Issue

    Serum uric acid concentration is a complex phenotype influenced by both genetic and environmental factors, as well as the interactions between them. Hyperuricemia results from an imbalance between endogenous production and the excretion of uric acid. In recent years, the clinical importance of hyperuricemia has increased, as the role of uric acid as an activator of the immune system deserves to be highlighted not only in the context of gout but also of a range of associated pathologies – such as cardiovascular diseases and metabolic syndrome. Elevated serum uric acid is considered to induce glomerular hypertension via increased vascular resistance and reduced kidney blood flow, serum uric acid is reported also as an important mediator of adipogenesis and lipogenesis. Remarkable advances in urate transporter studies and studies related to enzymes in metabolic pathways to uric acid have partly elucidated the pathogenesis of hyperuricemia - renal underexcretion of urate, due to the dysfunction of the ABCG2 high-capacity urate exporter, which is a major contributor. The potential role of urate-lowering therapy, in the management of hyperuricemia and the “non-gout diseases,” has been raised - however, treatment of asymptomatic hyperuricemia is not commonly implemented and according to the American College of Rheumatology guidelines, therapy is not recommended for people with asymptomatic hyperuricemia.

    This Special Issue of Exploration of Musculoskeletal Diseases journal focuses on recent advances in the field of primary hyperuricemia associated with increased uric acid production and/or decreased uric acid clearance concerning the molecular mechanism, as well as the clinical implication and implementation.   The goal is to stimulate research and clinical interest in this exciting field with the hope of improving our understanding of uric acid handling and its related influence. Expanding our knowledge of this common condition, hyperuricemia, will allow us to better understand the pathogenetic mechanism of gout and gout comorbidities, including the potential identification of new diagnostic and therapeutic strategies.

    Keywords: Hyperuricemia, gout

    Call for Papers

    Published Articles

    Open Access
    Uric acid in atherosclerosis and cardiovascular diseases: innocent bystander or ruthless killer?
    Medical attention to uric acid (UA) has been increasing in recent years, mainly because this molecule has been shown to be associated with increased cardiovascular risk, both in the general populati [...] Read more.
    Giovanni Cimmino ... Plinio Cirillo
    Published: June 03, 2024 Explor Musculoskeletal Dis. 2024;2:189–207
    DOI: https://doi.org/10.37349/emd.2024.00048
    Times Cited: 0
    Open Access
    Premature mortality with gout and hyperuricemia may be reduced by early resolution of comorbid obstructive sleep apnea
    Hyperuricemia is known to be a necessary and causal condition for gout, but much more prevalent than gout. Medicine has standardized treatments for gout, but has no such determination for asymptomat [...] Read more.
    Burton Abrams
    Published: August 31, 2023 Explor Musculoskeletal Dis. 2023;1:106–120
    DOI: https://doi.org/10.37349/emd.2023.00015
    Times Cited: 0