• Special Issue Topic

    Genetic and Epigenetic Control of Autophagy in Human Diseases

    Submission Deadline: March 31, 2024

    Guest Editors

    Dr. Jun Ren E-Mail

    Professor, Department of Cardiology, Fudan University Zhongshan Hospital, Shanghai, China

    Research Keywords: cardiovascular, metabolism, mitochondria, obesity, diabetes

    Dr. Muralikrishnan Dhanasekaran E-Mail

    Professor, Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, USA

    Research Keywords: pathophysiology, pharmacology and toxicology in dementia, movement disorders, addiction, hyperglycemia, aging

    About the Special Issue

    Ample of clinical and experimental studies have indicated the importance of autophagy and the ubiquitin-proteasome system (UPS) in the pathogenesis of human diseases including cancer, neurodegenerative disease and muscle disorders. Autophagy is essential for the removal of dysfunctional organelles and protein aggregates, whereas UPS is important for the quality control of proteins. Cardiovascular and endocrine metabolic systems are deemed particularly susceptible to aged or dysfunctional organelles and aggregation-prone proteins. Excessive or defective activity of the autophagy lysosome or ubiquitin-proteasome has been shown to lead to detrimental effects in cardiometabolic homeostasis. Understanding the pathological role of these degradative systems may provide novel therapeutic targets to counteract not only cardiovascular diseases but also metabolic anomalies. We invite investigators to contribute original research as well as review articles that will stimulate the continuing efforts towards understand the pathophysiology behind autophagy and UPS in the pathogenesis of human diseases. We are particularly interested in articles describing current concepts in the management of cardiometabolic diseases with a special focus on new concept of applying autophagy and protein quality control in the therapeutics of these comorbidities. 

    Keywords: autophagy, mitochondria, cardiovascular, metabolic, protein quality control, cell death

    Call for Papers

    Published Articles

    Open Access
    Autophagy and diabetes
    The current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medici [...] Read more.
    Milan Obradovic ... Esma R. Isenovic
    Published: August 31, 2023 Explor Med. 2023;4:576–588
    DOI: https://doi.org/10.37349/emed.2023.00162
    Times Cited: 0
    Open Access
    Autophagy in ischemic stroke: role of circular RNAs
    Stroke, a central nervous system (CNS) injury, is responsible for the second leading cause of death in the world, bringing a great burden on the world. Stroke is normally divided into ischemic and h [...] Read more.
    Yiting Hong ... Honghong Yao
    Published: August 31, 2023 Explor Med. 2023;4:471–486
    DOI: https://doi.org/10.37349/emed.2023.00157
    Times Cited: 0
    Open Access
    Oxidative stress, inflammation, dysfunctional redox homeostasis and autophagy cause age-associated diseases
    Aging and age-associated diseases (AADs) are growing risk factors in societies worldwide. During aging, there is an accumulation of excessive oxygen free radicals [reactive oxygen species (ROS)] and nitrogen free radicals [reactiv [...] Read more.
    Prasert Sobhon ... Sawaek Weerakiet
    Published: February 28, 2023 Explor Med. 2023;4:45–70
    DOI: https://doi.org/10.37349/emed.2023.00124