• 8 results in Exploration of Medicine
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    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging,  [...] Read more.
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. 2022;3:112–127
    DOI: https://doi.org/10.37349/emed.2022.00078
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    Open Access
    Original Article
    Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia
    Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously [...] Read more.
    Kristin E. Reeve ... Babbette LaMarca
    Published: February 25, 2022 Explor Med. 2022;3:99–111
    DOI: https://doi.org/10.37349/emed.2022.00077
    This article belongs to the special issue Angiotensins—A Century of Progress
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    Open Access
    Review
    Multi-faced roles of reactive oxygen species in anti-tumor T cell immune responses and combination immunotherapy
    T cells play a central role in anti-tumor immunity, and reactive oxygen species (ROS) lie at the crossroad on the anti-tumor T cell responses. To activate efficient T cell immunity, a moderate level [...] Read more.
    Tao Wang, Haiyan Xu
    Published: February 25, 2022 Explor Med. 2022;3:77–98
    DOI: https://doi.org/10.37349/emed.2022.00076
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
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    Open Access
    Editorial
    Elimination of hepatitis C virus infection in Europe: targeting the obstacles
    Dante Romagnoli
    Published: February 24, 2022 Explor Med. 2022;3:71–76
    DOI: https://doi.org/10.37349/emed.2022.00075
    This article belongs to the special issue Exploring Chronic Liver Disease
    Open Access
    Review
    Oxidative stress in obesity and insulin resistance
    Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published lite [...] Read more.
    Anastasija Panic ... Esma R. Isenovic
    Published: February 23, 2022 Explor Med. 2022;3:58–70
    DOI: https://doi.org/10.37349/emed.2022.00074
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
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    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole [...] Read more.
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. 2022;3:43–57
    DOI: https://doi.org/10.37349/emed.2022.00073
    This article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions
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    Review
    Nano-immunotherapeutics: targeting approach as strategic regulation at tumor microenvironment for cancer treatment
    Cancer is the leading cause of mortality worldwide, which necessitates our consideration related to novel treatment approach. Tumor cells at the tumor microenvironment (TME), regulate a plethora of  [...] Read more.
    Priyanka Singh ... Anita Kamra Verma
    Published: February 16, 2022 Explor Med. 2022;3:22–42
    DOI: https://doi.org/10.37349/emed.2022.00072
    This article belongs to the special issue Nanomedicine and Cancer Immunotherapy
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    Open Access
    Original Article
    Preclinical toxicity test results of a new antiviral–immune-modulator compound consisting of flavonoid molecules (COVID-19 clinical trial preliminary data)
    Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of bioavailability and molecular concentrations. The specific formula is then tested [...] Read more.
    Gürer G. Budak ... Orkun Tarkun
    Published: January 18, 2022 Explor Med. 2022;3:1–21
    DOI: https://doi.org/10.37349/emed.2022.00071
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