• Special Issue Topic

    Nanomaterials interaction with chemokines: perspectives for applied immunology

    Submission Deadline: January 31, 2023

    Guest Editor

    Dr. Giuseppe Bardi E-Mail

    NanoBioInteractions & Nanodiagnostics, Istituto Italiano di Tecnologia, Via Morego 30 - 16163 Genova, Italy

    Research Keywords: chemokines, immune system, innate immune responses, nanomaterials, signal transduction cross-talk

    About the Special Issue

    Chemokines (Chemo-attractant cyto-kines) are homeostatic or inflammatory 10 KDa-proteins characterized by cysteine to cysteine disulfide-bridges. More than 30 human chemokines have been discovered so far and their main task is ruling immune cell migration. Their receptors belong to the 7-trasmembrane G-protein coupled receptor family and some of them are incidentally HIV co-receptors. This discovery led to the development of several antagonists to induce negative signaling affecting immune response. Nanotechnologies can also be designed to exploit this ligand-receptor interaction. Surface chemical modification of nanomaterials with chemokines or receptor-derived peptides can find several applications in bio-medicine, from specific drug delivery to reduced cell migration. Nanomaterial with intrinsic ability to adsorb inflammatory chemokines, for example, could remove the exceeding molecules during pathology-induced cytokine storms, such as during sepsis or Covid 19. Most of these nano-tools are still on the research bench, but they show great potential in immunology.

    We warmly welcome your submissions for this Special Issue including (but not limited to) original papers regarding nanomaterial-chemokine interaction or nano-carriers for the released of chemokines, chemokine-derived peptides, antagonists, as well as interesting analysis of the growing literature in the field organized in review articles.

    Keywords: chemokines, chemokine receptors, nanomaterials, nanoparticles, immune response, inflammation, drug delivery, immune-diagnostics

    Call for Papers

    Published Articles

    Open Access
    Chemokine-targeted nanoparticles: stimulation of the immune system in cancer immunotherapy
    Surgery, chemotherapy, radiation therapy, and immunotherapy are potential therapeutic choices for many malignant and metastatic cancers. Despite adverse side effects and pain, surgery and chemothera [...] Read more.
    Ranjeet Singh ... Partha Pratim Manna
    Published: April 27, 2023 Explor Immunol. 2023;3:123–147
    DOI: https://doi.org/10.37349/ei.2023.00093
    Times Cited: 0
    Open Access
    Chemokines and nanomaterials: interaction for useful immune-applications
    Chemokines are homeostatic or inflammatory small proteins regulating immune cell migration and are structurally characterized by cysteine disulfide bridges. Around 50 human chemokines binding almost [...] Read more.
    Giuseppe Bardi
    Published: August 31, 2022 Explor Immunol. 2022;2:637–647
    DOI: https://doi.org/10.37349/ei.2022.00073