• Special Issue Topic

    Interplay of Stem Cells and Immunology in Regenerative Medicine

    Submission Deadline: August 31, 2022

    Guest Editor

    Dr. Sunil K Arora E-Mail

    Professor of Department of Immunopathology, Head of Department of Translational & Regenerative Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh-160012, India

    Research Keywords: Immunology, infectious diseases, HIV, HCV, stem cells

    About the Special Issue

    There has been a rapid growth in stem cell research in the field of regenerative medicine largely because of the potential of stem cells to differentiate into various organ-specific cells/tissues under tissue-specific microenvironment. Studies in this field are mainly focused on understanding the pathways of regeneration of damaged tissues with the use of these cells, without being attacked by the immune system. As a large number of clinical trials are being started with stem cells as therapeutic agents, yet the issues related to the immunological consequences of these cell-based therapies have not been understood properly. Never-the-less researchers are making sincere efforts to address the immunological questions for stem cell based therapies. Various descriptions have been applied to stem cell therapies from immune privileged to immune evasive or weakly immunogenic, but many of these characteristics are ascribed from in vitro assessments and how these results translate to the clinical setting is not clear. Many factors may be important in determining the susceptibility of transplanted cells to host immune rejection; allogeneic versus autologous cells, cell culture conditions, cell maturation, level of cellular manipulation, presence of inflammation and the immunological status of the patient. besides the properties of the administered cells, the relative immune tolerance of the site of administration and the immune status of the host or patient.

    In order to get more insight into these important issues related to Immunological consequences and stem cell therapy, we invite articles related to the field.

    Keywords: Stem cell biology, immune-mechanisms, immune-consequences, immune-rejection, Stem cell transplantation, induced pluripotent stem cells, regenerative medicine

    Call for Papers

    Published Articles

    Open Access
    Immune evasion by cancer stem cells ensures tumor initiation and failure of immunotherapy
    Cancer stem cells (CSCs) are a small subpopulation of cells that drive the formation and progression of tumors. However, during tumor initiation, how CSCs communicate with neighbouring immune cells  [...] Read more.
    Sourio Chakraborty ... Tanya Das
    Published: August 31, 2023 Explor Immunol. 2023;3:384–405
    DOI: https://doi.org/10.37349/ei.2023.00108
    Open Access
    Immune response: the Achilles’ heel of the stem cell-based regenerative therapies
    Besides trauma, several pathological conditions which directly affect the normal functioning of organs, require new therapeutic strategies to repair damaged or diseased tissues. Tissue regeneration  [...] Read more.
    Cláudia S. Oliveira, Freni K. Tavaria
    Published: June 30, 2023 Explor Immunol. 2023;3:233–254
    DOI: https://doi.org/10.37349/ei.2023.00100
    Times Cited: 0
    Open Access
    Mesenchymal stem cells—the master immunomodulators
    Mesenchymal stem/stromal cells (MSCs) are known as multipotent cells due to their ability to differentiate into various cell lineages of mesoderm origin. Recent developments in stem cell biology hav [...] Read more.
    Mehak Vohra, Sunil K. Arora
    Published: April 27, 2023 Explor Immunol. 2023;3:104–122
    DOI: https://doi.org/10.37349/ei.2023.00092
    Times Cited: 0