• Special Issue Topic

    DNA Sensing in Lung Inflammation

    Submission Deadline: November 30, 2022

    Guest Editor

    Dr. Bernhard Ryffel E-Mail

    Professor, INEM, UMR7355, CNRS, University of Orleans, France

    Research Keywords: mechanisms of inflammation, innate immune danger sensing, inflammasome activation, IL-33 and Th17/Th22 differentiation

    About the Special Issue

    Cells stress or death causes the release of danger signals such as nucleic acids activating inflammatory pathways. The focus here is the role of free nucleic acids driven inflammatory respiratory diseases due to exposure to smoke, pollutants including ozone, chemicals, allergen and infection resulting in chronic progressive inflammation, emphysema,  fibrosis and systemic effects. The cellular mechanisms of cGAS and STING activation, the cross-talk with the inflammasomes and related pathways are reviewed and potential therapeutic targets are welcome.

    Keywords: DNA, lung, inflammation

    Call for Papers

    Published Articles

    Open Access
    Inflammasomes driven inflammation in lung cancer revisited: a short review
    Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among othe [...] Read more.
    Vitor Rodrigues da Costa ... Rodrigo Pinheiro Araldi
    Published: March 14, 2023 Explor Immunol. 2023;3:70–81
    DOI: https://doi.org/10.37349/ei.2023.00090
    Times Cited: 0
    Open Access
    SARS-CoV-2 infection activates the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in the lung: a review
    The infection of COVID-19 is directly linked to the destruction of lung epithelial cells, and the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS [...] Read more.
    Gislei F. Aragão ... Sara Lívia M. Teixeira
    Published: February 28, 2023 Explor Immunol. 2023;3:56–69
    DOI: https://doi.org/10.37349/ei.2023.00089
    Times Cited: 0
    Open Access
    Sensing of viral lung infections by cGAS-STING
    Lower respiratory tract infections caused over 4 million deaths per year worldwide, especially in low-income countries. Viral respiratory infections often occur as rapidly spreading seasonal endemic [...] Read more.
    Lei Fang, Michael Roth
    Published: May 30, 2022 Explor Immunol. 2022;2:303–319
    DOI: https://doi.org/10.37349/ei.2022.00052