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    Mucosal Immune Cells - Border Protection or Entrance Gate?

    Submission Deadline: July 31, 2023

    Guest Editor

    Jochen Mattner E-Mail

    Associate Professor, Institute of Clinical Microbiology, Immunology and Hygiene, FAU Erlangen-Nürnberg and UKER, Erlangen, Germany

    Research Keywords: Host-pathogen interactions, mucosal immunology, innate immune responses, immune-mediated diseases


    About the Special Issue

    Multiple immune cell populations line the muco-epithelial borders of our body. Continuous exposure of these interfaces to the environment as well as to diverse microorganisms and their metabolites reflects the biological necessity for a multifaceted, integrated epithelial and immune cell-mediated regulatory system. Thus, the cellular components of this regulatory system need to discriminate invading pathogens from harmless microbiota to which they form the first line of defense or have to be tolerant to, respectively. For these complex interactions underlying the balance between pro- and anti-inflammatory processes, myeloid cell, regulatory T cell or intraepithelial lymphocyte populations are equipped with unique receptors and signaling circuits. Disruptions of these versatile processes can turn regulatory into inflammatory immune responses that underlie the pathogenesis of many complex immune-mediated disorders. Elucidation of the mechanisms through which disrupted signaling circuits and/or altered receptor expression/function turn regulatory into inflammatory immune cells can help to devise targeted and personalized tools for the diagnosis, therapy and prevention of immune-mediated disorders and/or infectious disease.

    In this Special Issue, we welcome original articles, reviews, case reports, preclinical and clinical studies.

    Keywords: mucosa-associated microenvironment, auto-immunity, immunotherapy, immune evasion, T regulatory cells, intra-epithelial lymphovytes, microbiota, metabolites, NGS, trascriptomics, metabolomics, myeloid cell populations, cell signaling, disease pathogenesis, colonization resostance, infectious disease

    Call for Papers

    Published Articles

    • Submit a Manuscript
    • Aims and Scope
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    • Ongoing Special Issues
      New insights in cancer immunology: the role of microbiota from immunosurveillance to immunotherapy
      Immunology, Immunopathology and Genomics of SARS-COV-2
      Interplay of Stem Cells and Immunology in Regenerative Medicine
      Cytokines and Skin Diseases
      DNA Sensing in Lung Inflammation
      The Role of Adaptor Proteins in Lymphoid Cell Signaling
      Nanomaterials interaction with chemokines: perspectives for applied immunology
      Old and New Paradigms in Viral Vaccinology
      Autoantibodies Associated to Thrombosis and Hemostasis
      Immunosenescence: Mechanisms and Its Impact
      The Complement System in Health and Disease
      Chronic Inflammation and Autoimmunity
      Bioinformatics, Big Data, AI: Exploring Immunology
      Role of NK cells, Chemokines, and Pyroptosis in Melanoma Development or Treatment
      Immunoregulatory Function of Mesenchymal Stem Cells in Tissue Repair and Regeneration
      The Immune Signature of Microgravity
      Cell Biology and Treatment of Autoimmune Diseases
      Mucosal Immune Cells - Border Protection or Entrance Gate?
      Immunobiology of Dendritic Cells
      Neuroimmunology of Multiple Sclerosis: Exploring New Perspectives
      Physical Activity and Immune System in Chronic Diseases : Mechanisms and Insights
      Immunobiology and Inflammation in the Male Reproductive System
    • Completed Special Issues
      Cross Talk Among Skin Cells and Immune Cells
      Vaccine-induced Immune Responses Against SARS-CoV-2 Infections
      Human Reproduction: Involvement of the Immune System
      Interplay of γδ T cells and Tumor Cells
      The‌ ‌Sepsis‌ ‌induced‌ ‌Immune‌ ‌Conundrum
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