Exploration of Drug Science

Open Access Review

Inflammatory bowel disease in Africa: the current landscape of pharmacological treatments and the promise of emerging innovations

Murtada A. Oshi

Published: July 10, 2025 Explor Drug Sci. 2025;3:1008117

DOI: https://doi.org/10.37349/eds.2025.1008117

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8383 139 0

Open Access Review

Experimental and clinical tests of FDA-approved kinase inhibitors for the treatment of neurological disorders (update 2024)

Hassan Aliashrafzadeh ... Da Zhi Liu

Published: July 01, 2025 Explor Drug Sci. 2025;3:1008116

DOI: https://doi.org/10.37349/eds.2025.1008116

This article belongs to the special issue Leveraging the FDA-Approved Kinase Inhibitors to Treat Neurological Disorders

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10420 146 0

Open Access Original Article

A simple quantitative model for the prediction of exposure of renally excreted drugs in pregnant women: a comparison with whole body PBPK model

Iftekhar Mahmood

Published: July 01, 2025 Explor Drug Sci. 2025;3:1008115

DOI: https://doi.org/10.37349/eds.2025.1008115

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2335 48 0

Open Access Review

Erythrocyte binding peptides: a story in the search for a malaria vaccine

Mauricio Urquiza-Martinez ... Fanny Guzmán-Quimbayo

Published: June 25, 2025 Explor Drug Sci. 2025;3:1008114

DOI: https://doi.org/10.37349/eds.2025.1008114

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4827 117 0

Open Access Original Article

Interaction of brequinar and analogs with PD-L1: a molecular docking analysis

Gérard Vergoten, Christian Bailly

Published: June 09, 2025 Explor Drug Sci. 2025;3:1008113

DOI: https://doi.org/10.37349/eds.2025.1008113

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4050 94 0

Open Access Review

Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application

Dmitrii Platov ... Mikhail Drenichev

Published: May 29, 2025 Explor Drug Sci. 2025;3:1008112

DOI: https://doi.org/10.37349/eds.2025.1008112

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2346 66 0

Open Access Original Article

Cytochrome P450 2C9-mediated interactions: molecular docking studies of natural anti-arthritic compounds

Boon Hooi Tan ... Chin Eng Ong

Published: May 27, 2025 Explor Drug Sci. 2025;3:1008111

DOI: https://doi.org/10.37349/eds.2025.1008111

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2588 57 1

Open Access Review

Antimicrobial peptides: structure, function, mechanism of action and therapeutic applications in human diseases

Rahul Dilawari ... Neha Parmar

Published: May 09, 2025 Explor Drug Sci. 2025;3:1008110

DOI: https://doi.org/10.37349/eds.2025.1008110

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13769 370 2

Open Access Original Article

High-risk neuroblastoma stage 4 (NBS4): multi-target inhibitors for c-Src kinases (Csk) and retinoic acid (RA) signalling pathways

Amgad Gerges, Una Canning

Published: May 09, 2025 Explor Drug Sci. 2025;3:1008109

DOI: https://doi.org/10.37349/eds.2025.1008109

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2430 43 0

Open Access Original Article

Combinatorial and fragment-based in silico design of PI3K-alpha natural hybrid antagonists for breast cancer therapeutics

Navya Aggarwal ... Banashree Bondhopadhyay

Published: April 29, 2025 Explor Drug Sci. 2025;3:1008108

DOI: https://doi.org/10.37349/eds.2025.1008108

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3426 75 4

Open Access Original Article

Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids

David Chafi Zeitune ... Camilla Djenne Buarque

Published: April 21, 2025 Explor Drug Sci. 2025;3:1008107

DOI: https://doi.org/10.37349/eds.2025.1008107

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3383 96 2

Open Access Review

Natural products targeting cancer stem cells: a promising therapeutic approach

Julia K. Opara ... Shrikant Anant

Published: April 18, 2025 Explor Drug Sci. 2025;3:1008106

DOI: https://doi.org/10.37349/eds.2025.1008106

This article belongs to the special issue Remedial benefits of natural products in inflammation and cancer

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8301 212 9

Open Access Review

A narrative review on the role of gut microbiome, dietary strategies, and supplements in managing metabolic syndrome

Sunil Chopra ... Ramendra Pati Pandey

Published: April 14, 2025 Explor Drug Sci. 2025;3:1008105

DOI: https://doi.org/10.37349/eds.2025.1008105

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20548 267 4

Open Access Original Article

Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds

Lakshmi Mounika Kelam ... M. Elizabeth Sobhia

Published: April 10, 2025 Explor Drug Sci. 2025;3:1008104

DOI: https://doi.org/10.37349/eds.2025.1008104

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2944 62 0

Open Access Review

The use of peptides for deciphering the mechanism of EBV, HPV, and HCV invasion of human cells

Daniela Perdomo-Joven ... Mauricio Urquiza-Martinez

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008103

DOI: https://doi.org/10.37349/eds.2025.1008103

This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research

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6599 80 1

Open Access Review

Novel progression on clinical therapy of COVID-19: Western and Traditional Chinese Medicines

Yongjia Xiong ... Feiyue Xing

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008102

DOI: https://doi.org/10.37349/eds.2025.1008102

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6557 61 0

Open Access Review

Folic acid conjugated with serum albumin for nano- and submicron delivery systems for applications in therapy and diagnostics

Maria G. Gorobets ... Anna V. Bychkova

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008101

DOI: https://doi.org/10.37349/eds.2025.1008101

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4410 114 4

Open Access Original Article

Efficacy of propolis varnish in reducing Streptococcus mutans counts

Mariana Passos De Luca ... Vagner Rodrigues Santos

Published: March 20, 2025 Explor Drug Sci. 2025;3:100899

DOI: https://doi.org/10.37349/eds.2025.100899

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4277 114 1

Open Access Review

Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs

Tatiana Gudasheva ... Vladimir Dorofeev

Published: March 21, 2025 Explor Drug Sci. 2025;3:1008100

DOI: https://doi.org/10.37349/eds.2025.1008100

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3295 58 2

Open Access Review

Molecular mechanisms and therapeutic prospects of 4-aminobenzoic acid in neuropsychiatric disorders: a comprehensive review of neurotransmitter modulation, anti-inflammatory pathways, and antioxidant defense

Siyu Chen ... Yangyang Liu

Published: March 19, 2025 Explor Drug Sci. 2025;3:100898

DOI: https://doi.org/10.37349/eds.2025.100898

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4808 61 0