• Special Issue Topic

    Nutrition, Intestinal Barrier and Metabolic Liver Disease

    Submission Deadline: July 31, 2023

    Guest Editors

    Prof. Ina Bergheim E-Mail

    Department of Nutritional Sciences, Molecular Nutritional Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Wien, Austria

    Research Keywords: intestinal barrier, nutrition, bacterial endotoxin, alcoholic liver disease, non-alcoholic fatty liver disease, aging


    Dr. Annette Brandt E-Mail

    Department of Nutritional Sciences, Molecular Nutritional Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Wien, Austria

    Research Keywords: intestinal barrier, nutrition, PAMPs, non-alcoholic fatty liver disease, aging


    About the Special Issue

    Metabolic liver diseases like non-alcoholic fatty liver diseases (NAFLD) and alcohol-related liver diseases (ALD) are by now among the leading liver diseases in the world. Results of studies performed in both humans and model organisms suggest that nutrition and herein both the intake of certain nutrients and the dietary pattern are critical in the development of NAFLD and ALD. Furthermore, it has been shown that alterations of intestinal microbiota composition and intestinal barrier function are also key factors in the development of NAFLD and ALD. Indeed, interventions targeting nutritional intake and/ or intestinal microbiota composition and barrier function have been suggested to improve existing and to prevent or delay the development of NAFLD and ALD. However, despite a marked progress in the in the understanding of molecular mechanisms involved in the onset and the progression of both NAFLD and ALD universally accepted therapies besides life-style intervention e.g., in the case of NAFLD weight reduction and increased physical activity and in the case of ALD abstinence, being in both cases afflicted with high relapse rates, are still lacking.  

    In this Special Issue, we invite experts in the field to cover a wide range of topics of interest in enhancing our current understanding of the interaction of nutrition, intestinal barrier dysfunction and the development and progression of metabolic liver diseases, from bench to bedside. Our aim for a collection of a state-of-the-art original and review articles that may stimulate multidisciplinary research in this critical field of basic and clinical liver research.

    Keywords: Diet, dietary pattern, non-alcoholic fatty liver disease, alcohol-related liver disease, gut microbiota, insulin resistance, fatty liver, PAMPs, intestinal permeability

    Call for Papers

    Published Articles

    Open Access
    Review
    Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease—What are the proposed mechanisms?
    A high consumption of ultra-processed food (UPF) is a hallmark of Western diets that has been related to increased risk of non-communicable diseases. As an underlying mechanism, UPF may promote non- [...] Read more.
    Franziska A. Hägele ... Anja Bosy-Westphal
    Published: August 24, 2023 Explor Dig Dis. 2023;2:133–148
    DOI: https://doi.org/10.37349/edd.2023.00023
    View:705
    Download:32
    Times Cited: 0
    Open Access
    Review
    Alcohol-related liver disease: also a question of what you drink?
    Excessive alcohol intake is still among the leading causes of chronic liver diseases. Epidemiological studies suggest that per capita consumption of alcohol from various alcohol beverages e.g., beer [...] Read more.
    Finn Jung ... Ina Bergheim
    Published: June 30, 2023 Explor Dig Dis. 2023;2:118–132
    DOI: https://doi.org/10.37349/edd.2023.00022
    View:1194
    Download:52