• Special Issue Topic

    Small Airways Disease Across the Ages

    Submission Deadline: May 31, 2024

    Guest Editor

    Prof. Lombardi Carlo E-Mail

    Head of Departmental Unit of Allergology, Clinical Immunology & Pneumology, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy

    Research Keywords: Asthma, allergy, COPD, biological agents, specific allergen immunotherapy

    About the Special Issue

    Asthma is a chronic disease, affecting approximately 350 million people worldwide. Inflammation and remodeling in asthma involve the large airways, and it is now widely accepted that the small airways (those with an internal diameter <2 mm) are involved in the pathogenesis of asthma and are the major determinant of airflow obstruction in this disease. From a clinical perspective, small airways dysfunction (SAD) is associated with more severe bronchial hyperresponsiveness, worse asthma control and more exacerbations. Unlike the GOLD guidelines which, in their definition, identify COPD as a disease of the small airways, the Global Initiative for Asthma (GINA) guidelines do not refer to the prevalence and role of SAD in asthmatic patients. This decision seems surprising, given the growing body of compelling evidence accumulating pointing out the high prevalence of SAD in asthmatic patients and the importance of SAD in poor asthma control. Furthermore, and remarkably, SAD appears to possess the characteristics of a treatable pulmonary trait, making it certainly appealing for asthma control optimization and exacerbation rate reduction. 

    In this special issue, we address the most recent evidence on the role of SAD on asthma control and the important role of SAD not only in adult asthmatic patients but also in children and elderly asthmatics.

    Keywords: Small airways dysfunction (SAD), asthma, adults, children, elderly

    Call for Papers

    Published Articles

    Open Access
    Impulse oscillometry for the evaluation and management of pediatric asthma
    Asthma is the most common chronic disease during childhood. While most of characteristic structural changes in asthma have been identified in the large airways, there is a growing recognition of per [...] Read more.
    Pasquale Comberiati ... Diego Peroni
    Published: December 19, 2023 Explor Asthma Allergy. 2023;1:219–229
    DOI: https://doi.org/10.37349/eaa.2023.00022
    Times Cited: 0
    Open Access
    Mini Review
    Small airway dysfunction and impulse oscillometry in adult patients with asthma: recent findings
    Asthma is a respiratory disease affecting more than 300 million people around the world. Airflow obstruction and inflammation due to asthma usually involve large airways, but recently small airway i [...] Read more.
    Marcello Cottini ... Alvise Berti
    Published: October 31, 2023 Explor Asthma Allergy. 2023;1:163–173
    DOI: https://doi.org/10.37349/eaa.2023.00017
    Times Cited: 0
    Open Access
    Small airway dysfunction and obesity in asthmatic patients: a dangerous liaison?
    Asthma is a chronic condition characterized by inflammation throughout the entire bronchial airways. Recent findings suggest that ventilation inhomogeneity and small airway dysfunction (SAD) play a  [...] Read more.
    Jack Pepys ... Marcello Cottini
    Published: August 15, 2023 Explor Asthma Allergy. 2023;1:73–88
    DOI: https://doi.org/10.37349/eaa.2023.00010
    Times Cited: 0