From:  Managing severe oral mucositis using a novel combination of photobiomodulation therapy and pilocarpine hydrochloride: a case report

The patient’s condition at each stage. (A) Prior to the combined treatment session, the initial diagnosis revealed over 3 cm2 of ulcers and severe erythema, indicating severe oral mucositis (OMAS = 5) due to radiochemotherapy in a head and neck cancer patient; (B) second session, 72 hours after the initial combined treatment session, the ulcers still measured over 3 cm2, but the hard palate erythema was not severe (OMAS = 4.5); (C) third session, 72 hours after the second combined treatment session, the ulcers on the hard palate had improved and measured between 1–3 cm2 with no severe erythema (OMAS = 3.5); (D) fourth session, 72 hours after the third combined treatment session, the hard palate ulcers measured less than 1 cm2, and the soft palate measured more than 3 cm2 with no severe erythema (OMAS = 3); (E) the last treatment session, 72 hours after the fourth combined treatment session, the ulcers subsided, but no severe erythema remained (OMAS = 1); (F) four weeks’ follow-up, the oral mucosa revealed no ulcers or erythema (OMAS = 0). OMAS: oral mucositis assessment scale