Cardiovascular disease remains a leading cause of death in the United States [1]. Hypertension (HTN) is a key driver in the atherosclerotic process and increases the risk of stroke, myocardial infarction, chronic kidney disease, and heart failure. Guideline-based diagnostic criteria for HTN in youths vary by age [2], but recent NHANES data reported rates of HTN in patients aged 8–17 years to be 4.9% with 13% having abnormal blood pressure [3]. After the age of six years, essential HTN becomes the leading cause of abnormal blood pressure [4]. Along with inherited and anatomic etiologies of HTN, cardiometabolic risk factors such as obesity and insulin resistance have contributed to a three-fold increase in childhood HTN [5]. Children with obesity and children with HTN experience alterations in cardiac size and function as well as vascular changes that when found in adults, can be predictors of cardiovascular morbidity and mortality [6]. Furthermore, childhood blood pressure influences adult blood pressure measures. Data from the Bogalusa Heart Study demonstrated that elevated blood pressure persisted from childhood into adulthood [7]. A different cohort found that the number of abnormal blood pressure readings in childhood can be predictive of adult HTN [8]. While there are guidelines in the measurement of blood pressure assessment of vascular stiffness in pediatrics continues to evolve [9–11]. Lifestyle modifications such as dietary adjustments and increases in physical activity remain the cornerstones of treatment for youth with HTN, especially when secondary to overweight or obesity. When provided in a structured environment, engaging in regular physical activity and consuming a balanced diet with appropriate levels of sodium has been shown to reverse the early target organ changes seen in pediatric patients with HTN [12]. Pharmacotherapy is reserved for after a trial of lifestyle interventions and in those with symptomatic HTN, stage 2 HTN without a known cause, HTN associated with chronic kidney disease, or HTN in a patient with diabetes [2]. Antihypertensive agents are safe and effective therapies for pediatric HTN [13–15], but compliance with medications can be jeopardized by side effects, forgetfulness, expense, skepticism around need for treatment, and emotion regarding potential need for lifelong therapy [12]. Assessing compliance to lifestyle interventions poses several challenges. Food and beverage consumption logs rely on recall that lends itself to several biases. Another challenge in pediatric clinical practice remains the clinical constraints to the use of standardized diet and exercise prescriptions for HTN. Many times, a routine pediatric well child visit may not have the time or personnel to provide these prescriptions that structured preventive cardiology or multidisciplinary obesity medicine clinics with counsellors, nutritionists, and exercise physiologists may be able to deliver. The purpose of this review is to reflect on the literature regarding compliance rates among pediatric patients with HTN prescribed lifestyle therapies and medications, and to offer tools to pediatricians on how to improve the assessment of and compliance to guideline-recommended lifestyle therapies.

The World Health Organization (WHO) defines adherence as the extent to which a person’s behavior corresponds with agreed-upon recommendations from a health care provider [13]. In adults in the United States, the WHO estimates the adherence of patients with HTN to their treatment regimen to be 51%, with developed countries faring even worse [13]. In one sample of almost half a million adults, only 72% of patients with HTN were at least 80% compliant with their antihypertensive medication [14]. Poor adherence may result in uncontrolled HTN. There are numerous proposed mechanisms for poor treatment adherence. Patient-centered factors for poor blood pressure control include limited access to health care and inability to obtain prescriptions due to travel barriers [16]. Patient perceptions of medication efficacy and mistrust of medical professionals may also limit compliance [17]. Within pediatrics, medication non-compliance in children with chronic diseases has been associated with disease-related complications, increased number of emergency room visits, and hospitalizations [18]. In addition, medication adherence may reduce overall healthcare costs [18]. In a small sample of adolescents with essential HTN prescribed drug therapy, almost half had uncontrolled HTN [19]. However, those who were adherent to their medication prescription based upon pharmacy refill data exhibited better BP control. The authors also found that adherence determined by self-reporting did not correlate with blood pressure control and that there are potential racial disparities in medication adherence, and recommended leveraging the use of electronic medical records and pharmacy refill records as means of improving medication compliance.

Behavioral modifications targeting a heart-healthy diet and increasing physical activity are considered first-line treatments for pediatric HTN. While not traditionally considered during a visit for primary HTN, sleep hygiene plays a role in blood pressure regulation. Indeed, longer sleep duration in childhood has correlated with lower daytime blood pressures [20], keeping with the emphasis on adequate sleep in the American Heart Association’s Life’s Essential 8. Dietary changes emphasizing increased consumption of whole grains, vegetables, fruits, lean proteins, low-fat dairy, and fiber and limiting saturated fats, sugar-sweetened beverages, and sodium are recommended to improve cardiometabolic health. Unfortunately, American youths demonstrate poor adherence to national dietary guidelines. Banfield et al. [21] found that children and adolescents in the United States scored well below the accepted cutoff for good health on the Healthy Eating Index and suggested that diet in childhood is an important target to help reduce diet-related adult disease. Dietary sodium intake was positively correlated with systolic blood pressure in a large sample of United States children and adolescents [22]. Additionally, sodium consumption even during the neonatal period is associated with higher blood pressures in the adolescent years than those neonates who followed a low-sodium diet [23]. Youth who consumed higher amounts of fruits and vegetables were shown to have lower systolic blood pressure in a large cross-sectional analysis of adolescents [24]. The Dietary Approaches to Stop Hypertension (DASH) diet encompasses many of these recommendations and is the primary dietary strategy recommended by the American Academy of Pediatrics to combat pediatric HTN [2]. Components of the DASH pattern were associated with lower systolic and diastolic blood pressure in a subset of adolescent females followed over a 10-year period, even after adjusting for body mass index [25]. A longitudinal study involving children and adolescents showed that better adherence to the DASH style diet correlated with improved markers of cardiometabolic health, including blood pressure [26]. However, achieving these results often requires frequent contact points with patients via nutrition experts and sustained follow-up that may not be feasible for families and clinics to maintain [27].

Physical activity is an effective means of reducing BP in pediatric patients [28–30]. The optimal exercise prescription for children is still unknown; however, the American Academy of Pediatrics recommends 30–60 minutes of moderate to vigorous physical activity at least 3 to 5 days per week to help lower blood pressure. Unfortunately, survey data indicates that only 27% of adolescents met recommended amounts of physical activity [31]. More concerning is that objective data indicates even fewer (8–9%) meet the recommended guidelines [32], highlighting the discrepancy between self-reported levels of activity and objective measures that makes accurate assessments difficult in the clinical setting. From a patient perspective, one of the bigger problems today with diet and exercise recommendations is either “information overload” with contradictory guidance through the internet and social media versus a “one-size-fits-all” approach with vague non-specific information.

What follows is a real-world example of our clinical throughput at the Center for Cardiovascular Disease Prevention, Investigation, and Diagnostics (CVPID) clinic at Le Bonheur Children’s Hospital in Memphis, Tennessee. Our clinic utilizes a compilation of resources collected from multiple sources that we have found translates guideline-directed recommendations for screening and management of pediatric HTN into patient- and family-friendly educational materials. This is a single-center experience and may not be generalizable to all sites. Our goal is to provide pediatric clinics with a blueprint from which to implement strategies that may improve overall patient compliance, clinic satisfaction, and, most importantly, patient outcomes.

Adherence to lifestyle modifications is a critical component in the management of pediatric HTN. Strategies to enhance compliance must be age-appropriate, family centered, pragmatic, and tailored to the child and the family. A standardized approach with lifestyle survey tools as shared in this review may potentially help compliance and provide both clinician and family accountability. Our approach to managing pediatric HTN may not be generalizable to outside institutions. Our hospital serves a metropolitan area with a majority African American population located in the Mid-South of the United States Certain cultural and environmental factors may impact physical activity or dietary recommendations. Availability of professional dietary counseling via Registered Dieticians may also impact effectiveness of interventions. Above is a working protocol that is designed for use by clinicians to aid in providing evidence-based lifestyle counseling within a resource-limited setting.