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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" article-type="review-article">
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Explor Musculoskeletal Dis</journal-id>
<journal-id journal-id-type="publisher-id">EMD</journal-id>
<journal-title-group>
<journal-title>Exploration of Musculoskeletal Diseases</journal-title>
</journal-title-group>
<issn pub-type="epub">2836-6468</issn>
<publisher>
<publisher-name>Open Exploration Publishing</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.37349/emd.2024.00054</article-id>
<article-id pub-id-type="manuscript">100754</article-id>
<article-categories>
<subj-group>
<subject>Mini Review</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Screening for developmental dysplasia of the hip in Greece: current practice and future perspectives</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2960-8488</contrib-id>
<name>
<surname>Chlapoutakis</surname>
<given-names>Konstantinos</given-names>
</name>
<role content-type="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
<role content-type="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing—original draft</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing—review &amp; editing</role>
<xref ref-type="aff" rid="I1">
<sup>1</sup>
</xref>
<xref ref-type="aff" rid="I2">
<sup>2</sup>
</xref>
<xref ref-type="corresp" rid="cor1">
<sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kolovos</surname>
<given-names>Stylianos</given-names>
</name>
<role content-type="https://credit.niso.org/contributor-roles/investigation/">Investigation</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing—original draft</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing—review &amp; editing</role>
<xref ref-type="aff" rid="I3">
<sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pippidi</surname>
<given-names>Eleni</given-names>
</name>
<role content-type="https://credit.niso.org/contributor-roles/validation/">Validation</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing—review &amp; editing</role>
<xref ref-type="aff" rid="I4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9164-5511</contrib-id>
<name>
<surname>Dimitriou</surname>
<given-names>Rozalia</given-names>
</name>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing—original draft</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing—review &amp; editing</role>
<role content-type="https://credit.niso.org/contributor-roles/validation/">Validation</role>
<role content-type="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<xref ref-type="aff" rid="I5">
<sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0596-8331</contrib-id>
<name>
<surname>Skoulikaris</surname>
<given-names>Nikolaos</given-names>
</name>
<role content-type="https://credit.niso.org/contributor-roles/validation/">Validation</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing—review &amp; editing</role>
<xref ref-type="aff" rid="I6">
<sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5281-475X</contrib-id>
<name>
<surname>Raissaki</surname>
<given-names>Maria</given-names>
</name>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/">Writing—original draft</role>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing—review &amp; editing</role>
<role content-type="https://credit.niso.org/contributor-roles/validation/">Validation</role>
<role content-type="https://credit.niso.org/contributor-roles/supervision/">Supervision</role>
<xref ref-type="aff" rid="I7">
<sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="editor">
<name>
<surname>Pérez-Ruiz</surname>
<given-names>Fernando</given-names>
</name>
<role>Academic Editor</role>
<aff>Cruces University Hospital, Spain</aff>
</contrib>
</contrib-group>
<aff id="I1">
<sup>1</sup>Radiology Department, Vioapeikonisi Imaging Lab, 71202 Heraklion, Greece</aff>
<aff id="I2">
<sup>2</sup>Radiology Department, Asklepieon Crete Medical Center, 71201 Heraklion, Greece</aff>
<aff id="I3">
<sup>3</sup>Orthopaedic Clinic, General Hospital of Larissa, 41221 Larissa, Greece</aff>
<aff id="I4">
<sup>4</sup>Paediatric Clinic, General Hospital of Chios “Skilitseio”, 82131 Chios, Greece</aff>
<aff id="I5">
<sup>5</sup>Orthopaedic Department, Medical School, University of Crete, 71110 Heraklion, Greece</aff>
<aff id="I6">
<sup>6</sup>Radiology Department, St. Luke’s Hospital, 55236 Thessaloniki, Greece</aff>
<aff id="I7">
<sup>7</sup>Radiology Department, Medical School, University of Crete, 71110 Heraklion, Greece</aff>
<author-notes>
<corresp id="cor1">
<bold>
<sup>*</sup>Correspondence:</bold> Konstantinos Chlapoutakis, Radiology Department, Vioapeikonisi Imaging Lab, 71202 Heraklion, Greece. <email>kgchlapoutakis@outlook.com</email></corresp>
</author-notes>
<pub-date pub-type="ppub">
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>18</day>
<month>07</month>
<year>2024</year>
</pub-date>
<volume>2</volume>
<issue>4</issue>
<fpage>264</fpage>
<lpage>269</lpage>
<history>
<date date-type="received">
<day>09</day>
<month>03</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>11</day>
<month>04</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>© The Author(s) 2024.</copyright-statement>
<license xlink:href="https://creativecommons.org/licenses/by/4.0/">
<license-p>This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.</license-p>
</license>
</permissions>
<abstract>
<p id="absp-1">Screening for developmental dysplasia of the hip (DDH) in Greece is being performed according to the guidelines issued by the Institute of Child Health in 2015. Screening strategies include universal clinical screening and selective (based on clinical findings or risk factors) sonographic screening. Clinical examination is performed by neonatologists and paediatricians and findings are recorded in the baby’s Health-Book. Whenever clinical examination is suspicious (however non-specific), children are referred for an ultrasound scan and/or to a (paediatric) orthopaedic surgeon. In the case of a positive clinical examination, children are referred to a (paediatric) orthopaedic surgeon, who treats them, when needed. All types of abduction devices are used for treatment (Pavlik, Tubingen), as well as plaster cast, which is preferred in older babies. There are no official guidelines over the selection of the sonographic method for screening; however, the mostly used technique is Graf’s, according to publications from Greek centers. Training of operators on the sonographic examination technique is carried out during radiology residency, depending on hospital availability/expertise, through seminars with hands-on workshops and/or during fellowships. Radiologists and certified paediatric orthopaedic surgeons are the only ones legally allowed to perform neonatal/infantile hip sonography in Greece. Emphasis on the benefits of universal screening and standardized techniques are increasingly taught and repeated, which may eventually influence the decision-making process and standardize the performance of hip sonography within the next few years.</p>
</abstract>
<kwd-group>
<kwd>Developmental dysplasia of the hip</kwd>
<kwd>screening</kwd>
<kwd>hip ultrasound</kwd>
<kwd>hip sonography Greece</kwd>
<kwd>paediatric ultrasound</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<sec id="s1">
<title>Introduction</title>
<p id="p-1">Developmental dysplasia of the hip (DDH) is a broad term, covering a spectrum of abnormalities of the hip joint, which appear perinatally [<xref ref-type="bibr" rid="B1">1</xref>]. It is the most common musculoskeletal disorder of the newborn [<xref ref-type="bibr" rid="B2">2</xref>], with a complex etiology and a potential to cause permanent abnormalities to the joint, if not diagnosed and treated early [<xref ref-type="bibr" rid="B3">3</xref>, <xref ref-type="bibr" rid="B4">4</xref>].</p>
<p id="p-2">Screening for DDH during the postnatal period has been a source of debate and conflict [<xref ref-type="bibr" rid="B5">5</xref>]. Clinical examination [<xref ref-type="bibr" rid="B6">6</xref>] and imaging (mostly ultrasound [<xref ref-type="bibr" rid="B7">7</xref>] and radiography in selected cases [<xref ref-type="bibr" rid="B8">8</xref>]), form the basis for the diagnosis of the disorder and screening policies.</p>
<p id="p-3">This report briefly summarizes the published guidelines which currently form the basis of DDH screening in Greece, comments on the application of the current screening strategy and attempts to trace the future trends about DDH diagnosis and management.</p>
</sec>
<sec id="s2">
<title>Primary healthcare guidelines</title>
<p id="p-4">Screening for DDH in Greece is being performed according to the guidelines issued by the Institute of Child Health (<uri xlink:href="https://ich.gr/">https://ich.gr/</uri>), in 2015 [<xref ref-type="bibr" rid="B9">9</xref>]. Screening policy is presented in detail in the following table (<xref ref-type="table" rid="t1">Table 1</xref>).</p>
<table-wrap id="t1">
<label>Table 1</label>
<caption>
<p id="t1-p-1">Screening policy in Greece [<xref ref-type="bibr" rid="B9">9</xref>]</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th>
<bold>Timing of routine examinations</bold>
</th>
<th>
<bold>Policies and actions</bold>
</th>
</tr>
</thead>
<tbody>
<tr>
<td rowspan="2">1st–2nd week<break />(First routine examination)</td>
<td>DDH screening of all neonates, includes:<break />    (a) History (looking for risk factors)<sup>*</sup>.<break />    (b) Clinical examination (includes Barlow and Ortolani maneuvers).<break />         • Universal sonographic screening is not recommended.</td>
</tr>
<tr>
<td>Depending on the results:<break />    (a) Negative clinical examination<sup>**</sup> and no risk factors:<break />         • Clinical (re-)examination at the age of two (2) months.<break />    (b) Negative clinical examination<sup>**</sup> and risk factors present:<break />         • Perform hip ultrasound at six (6) weeks.<break />            i. In case of positive imaging findings:<break />               -Refer to a paediatric orthopaedic surgeon.<break />            ii. In case of negative imaging findings:<break />               -Clinical (re-)examination at the age of two (2) months.<break />    (c) Positive clinical examination<sup>**</sup>, irrespective of the presence or absence of risk factors: <break />         • Refer to a paediatric orthopaedic surgeon.<break />            -Use of a triple nappy is not recommended (insufficient evidence to support it, may delay appropriate treatment).</td>
</tr>
<tr>
<td rowspan="2">2 months<break />(Second routine examination)</td>
<td>DDH screening of all the infants, includes:<break />    (a) History (looking for risk factors)<sup>*</sup>.<break />    (b) Clinical examination (includes Barlow and Ortolani maneuvers).</td>
</tr>
<tr>
<td>Depending on the results:<break />    (a) Negative clinical examination<sup>**</sup>:<break />         • Follow up (no intervention).<break />    (b) Indicative/suspicious clinical findings (nonspecific findings, including asymmetries or restricted hip abduction, subtle “clicking” of the hip, with negative Barlow or Ortolani maneuvers):<break />         • Sonographic examination and/or referral to a paediatric orthopaedic surgeon.<break />    (c) Positive clinical examination<sup>**</sup>:<break />         • Referral to a paediatric orthopaedic surgeon.</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p id="t1-fn-1">DDH: developmental dysplasia of the hip; <sup>*</sup> : risk factors include breech presentation, positive family history (1st or 2nd degree relative), female gender, etc., also see <xref ref-type="table" rid="t2">Table 2</xref>; <sup>**</sup> : mainly based on Barlow and Ortolani maneuvers</p>
</fn>
<fn>
<p id="t1-fn-2">
<italic>Note.</italic> Translated from: “Monitoring children’s health in primary health care”. In: Antoniadou-Koumatou I, Panagiotopoloulos T, Attilakos A, editors. Athens: Institute of Child Health, 2015. (<uri xlink:href="https://www.moh.gov.gr/articles/health/dieythynsh-prwtobathmias-frontidas-ygeias/draseis-kai-programmata-agwghs-ygeias/oikogeneiakos-programmatismos/5256-paidiatrikes-kateythynthries-odhgies">https://www.moh.gov.gr/articles/health/dieythynsh-prwtobathmias-frontidas-ygeias/draseis-kai-programmata-agwghs-ygeias/oikogeneiakos-programmatismos/5256-paidiatrikes-kateythynthries-odhgies</uri>). Greek.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<p id="p-5">The above-mentioned screening strategy may be summarized in the following statements:</p>
<p id="p-6">
<list list-type="bullet">
<list-item>
<p>Universal clinical screening.</p>
</list-item>
<list-item>
<p>Selective (based on clinical findings or risk factors) sonographic screening.</p>
</list-item>
</list>
</p>
<p id="p-7">Risk factors, according to the recommendations, are included in <xref ref-type="table" rid="t2">Table 2</xref> [<xref ref-type="bibr" rid="B9">9</xref>].</p>
<table-wrap id="t2">
<label>Table 2</label>
<caption>
<p id="t2-p-1">Risk factors for DDH [<xref ref-type="bibr" rid="B9">9</xref>]</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th colspan="2">
<bold>Risk factors for DDH</bold>
</th>
</tr>
</thead>
<tbody>
<tr>
<td>Female sex</td>
<td>Other musculoskeletal disorders (metatarsus adductus, calcaneovalgus foot, talipes, torticollis)</td>
</tr>
<tr>
<td>Breech presentation</td>
<td>Oligohydramnios</td>
</tr>
<tr>
<td>Positive family history</td>
<td>Birth weight &gt; 4 kgr</td>
</tr>
<tr>
<td>Persistent “click” at clinical examination</td>
<td>Delivery after 42 weeks</td>
</tr>
<tr>
<td>Multiple gestation</td>
<td>Firstborn</td>
</tr>
<tr>
<td>Swaddling</td>
<td>Left hip</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p id="t2-fn-1">DDH: developmental dysplasia of the hip</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s3">
<title>DDH screening and clinical management in Greece</title>
<p id="p-8">True incidence of DDH in Greece has not been officially estimated. This is partly due to the fact that there is always a problem with the definition of the disorder, depending on the utilized diagnostic method (clinical examination, radiography, ultrasonography) and the diagnostic criteria (immaturity, dysplasia, dislocation), and partly due to the absence of a long-standing, unified, formally designed screening policy. As a result, epidemiological data are very limited.</p>
<p id="p-9">Clinical examination is mainly performed by neonatologists who normally examine the babies before discharge from the maternity unit and by paediatricians who perform clinical assessment of the infant’s development during visits for vaccinations, according to the national scheme. Examination results are recorded in the baby’s Health Book.</p>
<p id="p-10">Referral to a (paediatric) orthopaedic surgeon is performed in the case of a suspicious (a sonographic examination may also be requested) or positive clinical examination. Treatment, when needed, is performed by (paediatric) orthopaedic surgeons. All popular types of abduction devices are used (Pavlik, Tubingen), as well as plaster cast (hip spica), which is commonly used in older babies.</p>
<p id="p-11">There are no official guidelines over the selection of the sonographic method of choice for screening, however, publications originating from Greek screening locations indicate that the mostly used technique is Graf’s [<xref ref-type="bibr" rid="B10">10</xref>–<xref ref-type="bibr" rid="B13">13</xref>]. To our knowledge, there is no audit or evaluation of the efficacy of the operators, of treatment performance or of benefits of screening using the aforementioned policy, in Greece.</p>
<p id="p-12">Training of operators on the sonographic technique is carried out during radiology residency, depending on hospital availability/expertise, through seminars with hands-on workshops and/or during fellowships in national and international institutions. Only radiologists and certified paediatric orthopaedic surgeons are legally permitted to perform hip sonography in Greece. Structured training has been offered since 2009, through a series of training seminars, organized by the 2nd Orthopaedic Department of the Aghia Sofia Paediatric Hospital in Athens (Chair: Dr. Ioannis Anastasopoulos) and moderated by Professor Reinhard Graf. Since 2011, the Radiological Society of Crete, supported by the Radiology Department of the University of Crete (Chair: Professor Apostolos Karantanas), has offered five training courses in Heraklion, Crete. Notably, the first two have been moderated by Professor Reinhard Graf, himself. Training courses have also been organized under the auspices of the Radiological Society of Crete, in Chios and in Thessaloniki (Trainers: Dr. Konstantinos Chlapoutakis, Radiologist and Dr. Stylianos Kolovos, Orthopaedic Surgeon). The latest course has been held in Heraklion (2023), under the auspices of ICODE (International Interdisciplinary Consensus Committee on DDH Evaluation—<uri xlink:href="http://icode.expert">http://icode.expert</uri>). Training courses have already been planned for 2024.</p>
</sec>
<sec id="s4">
<title>Tracing the future</title>
<p id="p-13">Despite the fact that the benefits of universal screening have been thoroughly recorded, tested and verified [<xref ref-type="bibr" rid="B14">14</xref>–<xref ref-type="bibr" rid="B20">20</xref>], there is still an ongoing debate about the selection of the appropriate method to perform DDH screening [<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B21">21</xref>, <xref ref-type="bibr" rid="B22">22</xref>].</p>
<p id="p-14">Structured training has heavily affected attitudes on screening in certain geographic regions in Greece. A tendency towards universal sonographic screening is observed during the last few years in places where structured training has repeatedly taken place (including Crete and Chios), with promising results, thus promoting implementation of standardized performance of hip ultrasonography. Crete belongs to the geographic areas in Greece which have been considered to carry an increased incidence of DDH [<xref ref-type="bibr" rid="B10">10</xref>]. Consequently, paediatricians are inclined to refer neonates and infants for universal screening. There are no official data to support this regional practice, however, there is a strong possibility that a number of neonates/infants with negative or equivocal results from clinical examination have been successfully diagnosed and effectively treated.</p>
<p id="p-15">We are currently not aware of details about adherence to the national guidelines, current practices, and training on hip ultrasonography in several areas of Greece, especially the central and western parts of the country. More training courses, with the additional aid of a commercially available training phantom, have already been planned and are expected to further enhance the quality of practice, by increasing the number of trained operators/examiners. Furthermore, an effort to upgrade the screening policy to universal sonographic screening has been initiated, by communicating the literature updates to the scientific communities. These steps may eventually influence the decision-making process and standardize the performance of hip sonography within the next few years.</p>
</sec>
<sec id="s5">
<title>Conclusion</title>
<p id="p-16">Screening for DDH in Greece currently includes universal clinical screening and selective (risk-based) sonographic screening. Emphasis on the benefits of universal screening and standardized technique are increasingly taught and repeated, which may eventually influence the decision-making process and standardize the performance of hip sonography within the next few years.</p>
</sec>
</body>
<back>
<glossary>
<title>Abbreviations</title>
<def-list>
<def-item>
<term>DDH</term>
<def>
<p>developmental dysplasia of the hip</p>
</def>
</def-item>
</def-list>
</glossary>
<sec id="s6">
<title>Declarations</title>
<sec id="t-6-1">
<title>Author contributions</title>
<p>KC: Conceptualization, Investigation, Writing—original draft, Writing—review &amp; editing. SK: Investigation, Writing—original draft, Writing—review &amp; editing. EP and NS: Validation, Writing—review &amp; editing. RD and MR: Writing—original draft, Writing—review &amp; editing, Validation, Supervision. All authors read and approved the submitted version.</p>
</sec>
<sec id="t-6-2" sec-type="COI-statement">
<title>Conflicts of interest</title>
<p>The authors declare that they have no conflicts of interest.</p>
</sec>
<sec id="t-6-3">
<title>Ethical approval</title>
<p>Not applicable.</p>
</sec>
<sec id="t-6-4">
<title>Consent to participate</title>
<p>Not applicable.</p>
</sec>
<sec id="t-6-5">
<title>Consent to publication</title>
<p>Not applicable.</p>
</sec>
<sec id="t-6-6" sec-type="data-availability">
<title>Availability of data and materials</title>
<p>Not applicable.</p>
</sec>
<sec id="t-6-7">
<title>Funding</title>
<p>Not applicable.</p>
</sec>
<sec id="t-6-8">
<title>Copyright</title>
<p>© The Author(s) 2024.</p>
</sec>
</sec>
<ref-list>
<ref id="B1">
<label>1</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Agostiniani</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Atti</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Bonforte</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Casini</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Cirillo</surname>
<given-names>M</given-names>
</name>
<name>
<surname>De</surname>
<given-names>Pellegrin M</given-names>
</name>
<etal>et al.</etal>
</person-group>
<article-title>Recommendations for early diagnosis of Developmental Dysplasia of the Hip (DDH): working group intersociety consensus document</article-title>
<source>Ital J Pediatr</source>
<year iso-8601-date="2020">2020</year>
<volume>46</volume>
<elocation-id>150</elocation-id>
<pub-id pub-id-type="doi">10.1186/s13052-020-00908-2</pub-id>
<pub-id pub-id-type="pmid">33036652</pub-id>
<pub-id pub-id-type="pmcid">PMC7547432</pub-id>
</element-citation>
</ref>
<ref id="B2">
<label>2</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bialik</surname>
<given-names>V</given-names>
</name>
<name>
<surname>Bialik</surname>
<given-names>GM</given-names>
</name>
<name>
<surname>Blazer</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Sujov</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Wiener</surname>
<given-names>F</given-names>
</name>
<name>
<surname>Berant</surname>
<given-names>M</given-names>
</name>
</person-group>
<article-title>Developmental dysplasia of the hip: a new approach to incidence</article-title>
<source>Pediatrics</source>
<year iso-8601-date="1999">1999</year>
<volume>103</volume>
<fpage>93</fpage>
<lpage>9</lpage>
<pub-id pub-id-type="doi">10.1542/peds.103.1.93</pub-id>
<pub-id pub-id-type="pmid">9917445</pub-id>
</element-citation>
</ref>
<ref id="B3">
<label>3</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Nemeth</surname>
<given-names>BA</given-names>
</name>
<name>
<surname>Narotam</surname>
<given-names>V</given-names>
</name>
</person-group>
<article-title>Developmental dysplasia of the hip</article-title>
<source>Pediatr Rev</source>
<year iso-8601-date="2012">2012</year>
<volume>33</volume>
<fpage>553</fpage>
<lpage>61</lpage>
<pub-id pub-id-type="doi">10.1542/pir.33-12-553</pub-id>
<pub-id pub-id-type="pmid">23204397</pub-id>
</element-citation>
</ref>
<ref id="B4">
<label>4</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Engesæter</surname>
<given-names>IØ</given-names>
</name>
<name>
<surname>Lehmann</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Laborie</surname>
<given-names>LB</given-names>
</name>
<name>
<surname>Lie</surname>
<given-names>SA</given-names>
</name>
<name>
<surname>Rosendahl</surname>
<given-names>K</given-names>
</name>
<name>
<surname>Engesæter</surname>
<given-names>LB</given-names>
</name>
</person-group>
<article-title>Total hip replacement in young adults with hip dysplasia: age at diagnosis, previous treatment, quality of life, and validation of diagnoses reported to the Norwegian Arthroplasty Register between 1987 and 2007</article-title>
<source>Acta Orthop</source>
<year iso-8601-date="2011">2011</year>
<volume>82</volume>
<elocation-id>149−54</elocation-id>
<pub-id pub-id-type="doi">10.3109/17453674.2011.566146</pub-id>
<pub-id pub-id-type="pmid">21434808</pub-id>
<pub-id pub-id-type="pmcid">PMC3235283</pub-id>
</element-citation>
</ref>
<ref id="B5">
<label>5</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Biedermann</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Eastwood</surname>
<given-names>DM</given-names>
</name>
</person-group>
<article-title>Universal or selective ultrasound screening for developmental dysplasia of the hip? A discussion of the key issues</article-title>
<source>J Child Orthop</source>
<year iso-8601-date="2018">2018</year>
<volume>12</volume>
<elocation-id>296−301</elocation-id>
<pub-id pub-id-type="doi">10.1302/1863-2548.12.180063</pub-id>
<pub-id pub-id-type="pmid">30154918</pub-id>
<pub-id pub-id-type="pmcid">PMC6090188</pub-id>
</element-citation>
</ref>
<ref id="B6">
<label>6</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Shaw</surname>
<given-names>BA</given-names>
</name>
<name>
<surname>Segal</surname>
<given-names>LS</given-names>
</name>
<collab>SECTION ON ORTHOPAEDICS</collab>
<name>
<surname>Otsuka</surname>
<given-names>NY</given-names>
</name>
<name>
<surname>Schwend</surname>
<given-names>RM</given-names>
</name>
<name>
<surname>Ganley</surname>
<given-names>TJ</given-names>
</name>
<name>
<surname>Herman</surname>
<given-names>MJ</given-names>
</name>
<name>
<surname>Hyman</surname>
<given-names>JE</given-names>
</name>
<name>
<surname>Shaw</surname>
<given-names>BA</given-names>
</name>
<etal>et al.</etal>
</person-group>
<article-title>Evaluation and Referral for Developmental Dysplasia of the Hip in Infants</article-title>
<source>Pediatrics</source>
<year iso-8601-date="2016">2016</year>
<volume>138</volume>
<elocation-id>e20163107</elocation-id>
<pub-id pub-id-type="doi">10.1542/peds.2016-3107</pub-id>
<pub-id pub-id-type="pmid">27940740</pub-id>
</element-citation>
</ref>
<ref id="B7">
<label>7</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Graf</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Hip sonography: background; technique and common mistakes; results; debate and politics; challenges</article-title>
<source>Hip Int</source>
<year iso-8601-date="2017">2017</year>
<volume>27</volume>
<fpage>215</fpage>
<lpage>9</lpage>
<pub-id pub-id-type="doi">10.5301/hipint.5000514</pub-id>
<pub-id pub-id-type="pmid">28497455</pub-id>
</element-citation>
</ref>
<ref id="B8">
<label>8</label>
<element-citation publication-type="book">
<person-group person-group-type="author">
<name>
<surname>Tönnis</surname>
<given-names>D</given-names>
</name>
</person-group>
<source>General Radiography of the Hip Joint</source>
<comment>Congenital Dysplasia and Dislocation of the Hip in Children and Adults. Springer Berlin, Heidelberg; 1987. pp. 100−42.</comment>
<pub-id pub-id-type="doi">10.1007/978-3-642-71038-4_9</pub-id>
</element-citation>
</ref>
<ref id="B9">
<label>9</label>
<element-citation publication-type="book">
<person-group person-group-type="author">
<name>
<surname>Antoniadou-Koumatou</surname>
<given-names>I</given-names>
</name>
<name>
<surname>Panagiotopoulos</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Attilakos</surname>
<given-names>A</given-names>
</name>
</person-group>
<source>Monitoring children’s health in primary health care</source>
<publisher-loc>Athens</publisher-loc>
<publisher-name>Institute of Child Health</publisher-name>
<year iso-8601-date="2015">2015</year>
<comment>Greek.</comment>
</element-citation>
</ref>
<ref id="B10">
<label>10</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Giannakopoulou</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Aligizakis</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Korakaki</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Velivasakis</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Hatzidaki</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Manoura</surname>
<given-names>A</given-names>
</name>
<etal>et al.</etal>
</person-group>
<article-title>Neonatal screening for developmental dysplasia of the hip on the maternity wards in Crete, Greece. Correlation to risk factors</article-title>
<source>Clin Exp Obstet Gynecol</source>
<year iso-8601-date="2002">2002</year>
<volume>29</volume>
<fpage>148</fpage>
<lpage>52</lpage>
<pub-id pub-id-type="pmid">12171320</pub-id>
</element-citation>
</ref>
<ref id="B11">
<label>11</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Dragonas</surname>
<given-names>CG</given-names>
</name>
<name>
<surname>Kottaridou</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Vampertzis</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Abbakr</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Taha</surname>
<given-names>N</given-names>
</name>
<name>
<surname>Manoukian</surname>
<given-names>D</given-names>
</name>
</person-group>
<article-title>Length of treatment and ultrasound timing in infants with developmental dysplasia of the hip</article-title>
<source>Eur J Orthop Surg Traumatol</source>
<year iso-8601-date="2024">2024</year>
<volume>34</volume>
<elocation-id>1079−86</elocation-id>
<pub-id pub-id-type="doi">10.1007/s00590-023-03771-z</pub-id>
<pub-id pub-id-type="pmid">37934277</pub-id>
</element-citation>
</ref>
<ref id="B12">
<label>12</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kolovos</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Sioutis</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Papakonstantinou</surname>
<given-names>ME</given-names>
</name>
<name>
<surname>Serenidis</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Altsitzioglou</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Karampikas</surname>
<given-names>V</given-names>
</name>
<etal>et al.</etal>
</person-group>
<article-title>Ultrasonographic screening for developmental dysplasia of the hip: the Graf method revisited</article-title>
<source>Eur J Orthop Surg Traumatol</source>
<year iso-8601-date="2024">2024</year>
<volume>34</volume>
<elocation-id>723−34</elocation-id>
<pub-id pub-id-type="doi">10.1007/s00590-023-03767-9</pub-id>
<pub-id pub-id-type="pmid">37884843</pub-id>
</element-citation>
</ref>
<ref id="B13">
<label>13</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chatziravdeli</surname>
<given-names>V</given-names>
</name>
<name>
<surname>Kazas</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Metaxiotis</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Chatziioannidis</surname>
<given-names>I</given-names>
</name>
<name>
<surname>Mitsiakos</surname>
<given-names>G</given-names>
</name>
<name>
<surname>Diamanti</surname>
<given-names>E</given-names>
</name>
</person-group>
<article-title>Sonographic Hip Angles in Relation to Gestational Age of Neonates. A Prospective, Cohort in the Population of Northern Greece</article-title>
<source>Arch Bone Jt Surg</source>
<year iso-8601-date="2023">2023</year>
<volume>11</volume>
<elocation-id>197−205</elocation-id>
<pub-id pub-id-type="doi">10.22038/ABJS.2022.67942.3219</pub-id>
<pub-id pub-id-type="pmid">37168591</pub-id>
<pub-id pub-id-type="pmcid">PMC10165202</pub-id>
</element-citation>
</ref>
<ref id="B14">
<label>14</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Thallinger</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Pospischill</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Ganger</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Radler</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Krall</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Grill</surname>
<given-names>F</given-names>
</name>
</person-group>
<article-title>Long-term results of a nationwide general ultrasound screening system for developmental disorders of the hip: the Austrian hip screening program</article-title>
<source>J Child Orthop</source>
<year iso-8601-date="2014">2014</year>
<volume>8</volume>
<elocation-id>3−10</elocation-id>
<pub-id pub-id-type="doi">10.1007/s11832-014-0555-6</pub-id>
<pub-id pub-id-type="pmid">24488847</pub-id>
<pub-id pub-id-type="pmcid">PMC3935031</pub-id>
</element-citation>
</ref>
<ref id="B15">
<label>15</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Tschauner</surname>
<given-names>C</given-names>
</name>
<name>
<surname>Fürntrath</surname>
<given-names>F</given-names>
</name>
<name>
<surname>Saba</surname>
<given-names>Y</given-names>
</name>
<name>
<surname>Berghold</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Radl</surname>
<given-names>R</given-names>
</name>
</person-group>
<article-title>Developmental dysplasia of the hip: Impact of sonographic newborn hip screening on the outcome of early treated decentered hip joints—a single center retrospective comparative cohort study based on Graf’s method of hip ultrasonography</article-title>
<source>J Child Orthop</source>
<year iso-8601-date="2011">2011</year>
<volume>5</volume>
<fpage>415</fpage>
<lpage>24</lpage>
<pub-id pub-id-type="doi">10.1007/s11832-011-0366-y</pub-id>
<pub-id pub-id-type="pmid">23205143</pub-id>
<pub-id pub-id-type="pmcid">PMC3221760</pub-id>
</element-citation>
</ref>
<ref id="B16">
<label>16</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>von Kries</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Ihme</surname>
<given-names>N</given-names>
</name>
<name>
<surname>Altenhofen</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Niethard</surname>
<given-names>FU</given-names>
</name>
<name>
<surname>Krauspe</surname>
<given-names>R</given-names>
</name>
<name>
<surname>Rückinger</surname>
<given-names>S</given-names>
</name>
</person-group>
<article-title>General Ultrasound Screening Reduces the Rate of First Operative Procedures for Developmental Dysplasia of the Hip: A Case-Control Study</article-title>
<source>J Pediatr</source>
<year iso-8601-date="2012">2012</year>
<volume>160</volume>
<fpage>271</fpage>
<lpage>5</lpage>
<pub-id pub-id-type="doi">10.1016/j.jpeds.2011.08.037</pub-id>
<pub-id pub-id-type="pmid">21962602</pub-id>
</element-citation>
</ref>
<ref id="B17">
<label>17</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Wirth</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Stratmann</surname>
<given-names>L</given-names>
</name>
<name>
<surname>Hinrichs</surname>
<given-names>F</given-names>
</name>
</person-group>
<article-title>Evolution of late presenting developmental dysplasia of the hip and associated surgical procedures after 14 years of neonatal ultrasound screening</article-title>
<source>J Bone Joint Surg Br</source>
<year iso-8601-date="2004">2004</year>
<volume>86</volume>
<elocation-id>585−9</elocation-id>
<pub-id pub-id-type="pmid">15174558</pub-id>
</element-citation>
</ref>
<ref id="B18">
<label>18</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>O’Beirne</surname>
<given-names>JG</given-names>
</name>
<name>
<surname>Chlapoutakis</surname>
<given-names>K</given-names>
</name>
<name>
<surname>Alshryda</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Aydingoz</surname>
<given-names>U</given-names>
</name>
<name>
<surname>Baumann</surname>
<given-names>T</given-names>
</name>
<name>
<surname>Casini</surname>
<given-names>C</given-names>
</name>
<etal>et al.</etal>
</person-group>
<article-title>International Interdisciplinary Consensus Meeting on the Evaluation of Developmental Dysplasia of the Hip</article-title>
<source>Ultraschall Med</source>
<year iso-8601-date="2019">2019</year>
<volume>40</volume>
<fpage>454</fpage>
<lpage>64</lpage>
<pub-id pub-id-type="doi">10.1055/a-0924-5491</pub-id>
<pub-id pub-id-type="pmid">31195424</pub-id>
</element-citation>
</ref>
<ref id="B19">
<label>19</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ömeroğlu</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Kapıcıoğlu</surname>
<given-names>MİS</given-names>
</name>
<name>
<surname>Korkusuz</surname>
<given-names>F</given-names>
</name>
</person-group>
<article-title>Newborn hip screening experience in Türkiye</article-title>
<source>Explor Musculoskeletal Dis</source>
<year iso-8601-date="2024">2024</year>
<volume>2</volume>
<fpage>69</fpage>
<lpage>74</lpage>
<pub-id pub-id-type="doi">10.37349/emd.2024.00035</pub-id>
</element-citation>
</ref>
<ref id="B20">
<label>20</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Ömeroğlu</surname>
<given-names>H</given-names>
</name>
<name>
<surname>Yüksel</surname>
<given-names>S</given-names>
</name>
<name>
<surname>Demir</surname>
<given-names>P</given-names>
</name>
<name>
<surname>Alexiev</surname>
<given-names>V</given-names>
</name>
<name>
<surname>Alsiddiky</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Anticevic</surname>
<given-names>D</given-names>
</name>
<etal>et al.</etal>
</person-group>
<article-title>An Eastern Europe and Middle East multinational expert Delphi consensus study on the prevention, diagnosis, and treatment of developmental dysplasia of the hip before walking age</article-title>
<source>Int Orthop</source>
<year iso-8601-date="2024">2024</year>
<volume>48</volume>
<fpage>1373</fpage>
<lpage>80</lpage>
<pub-id pub-id-type="doi">10.1007/s00264-023-06077-1</pub-id>
<pub-id pub-id-type="pmid">38150007</pub-id>
</element-citation>
</ref>
<ref id="B21">
<label>21</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Westacott</surname>
<given-names>DJ</given-names>
</name>
<name>
<surname>Butler</surname>
<given-names>D</given-names>
</name>
<name>
<surname>Shears</surname>
<given-names>E</given-names>
</name>
<name>
<surname>Cooke</surname>
<given-names>SJ</given-names>
</name>
<name>
<surname>Gaffey</surname>
<given-names>A</given-names>
</name>
</person-group>
<article-title>Universal versus selective ultrasound screening for developmental dysplasia of the hip: a single-centre retrospective cohort study</article-title>
<source>J Pediatr Orthop B</source>
<year iso-8601-date="2018">2018</year>
<volume>27</volume>
<fpage>387</fpage>
<lpage>90</lpage>
<pub-id pub-id-type="doi">10.1097/BPB.0000000000000508</pub-id>
<pub-id pub-id-type="pmid">29578934</pub-id>
</element-citation>
</ref>
<ref id="B22">
<label>22</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gray</surname>
<given-names>J</given-names>
</name>
<name>
<surname>Toledo</surname>
<given-names>A</given-names>
</name>
<name>
<surname>Haynes</surname>
<given-names>J</given-names>
</name>
</person-group>
<article-title>Is universal ultrasound screening for developmental DDH in newborns better than physical examination screening or selective ultrasound screening?</article-title>
<source>Evidence-Based Practice</source>
<year iso-8601-date="2019">2019</year>
<volume>22</volume>
<elocation-id>15−7</elocation-id>
<pub-id pub-id-type="doi">10.1097/EBP.0000000000000331</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
</article>